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Aerius uses: Aerius 5 mgDesloratadineAerius is a nonsedating antihistamine known as desloratadine 5 mg. It is a once-daily treatment for seasonal allergic rhinitis (SAR). The most common treatment-related side effects with desloratadine / Aerius are headache, dry mouth and fatigue. These occurred with an incidence rate similar to placebo. Aerius descriptionDesloratadine (des-LOR-at-a-deen)is an antihistamine. It is used to relieve the symptoms of hay fever and hives of the skin. Antihistamines work by preventing the effects of a substance called histamine, which is produced by the body. Histamine can cause itching, sneezing, runny nose, and watery eyes. Also, in some persons histamine can close up the bronchial tubes (air passages of the lungs) and make breathing difficult. Histamine can also cause some persons to have hives, with severe itching of the skin.